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KMID : 0367419970400071021
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Journal of Korean Pediatric Society
1997 Volume.40 No. 7 p.1021 ~ p.1025
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A Case of Chronic Granulomatous Disease Which is Improved by Interferon-gamma Therapy
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김재춘
박순성/윤명자/금동혁
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Abstract
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Chronic granulomatous disease is a group of rare disorders characterized by a disease of oxidative metabolism of phagocytes with deficit of antimicrobial activity. Also, it has clinical features of chronic pyogenic infection, granuloma formation, hypergammaglobulinemia, anemia and leukocytosis. We experienced a case of chronic granulomatous disease with chronic recurrent infection, hypergammaglobulinemia and liver abscess. It was confirmed by modified NBT test. The result of patient' s NBT test was less than 11%. The patient received subcutaneous injection of interferon-γ, 200 million unit(0.1mg/m2 of body surface area per dose), on three consecutive days per week for 3 weeks and her symptom was improved. Then, we report a case of chronic granulomatous disease which is improved by interferon-γ therapy with brief review of literature.
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KEYWORD
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Chionic granulomatous disease/Interferon-gamma therapy
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